王凯（Wang Kai）

研究工作简介

王凯，博士，教授，博士生导师。主要从事光动力-光热药物研究与制药工艺开发及生产过程控制等方面的研究工作。主持国家自然科学基金青年基金项目1项、湖北省教育厅科学研究计划重点项目1项、湖北省教育厅科学研究计划重点项目1项，其他项目17项。在ACS Applied materials & Interfaces、Journal of Cleaner Production等国内外学术刊物上发表科研论文50余篇，其中SCI收录28余篇；获授权发明专利11项。获湖北省科学技术奖发明奖三等奖1项。

代表性成果

1.      Fengshou Wu^*, Li Chen, Liangliang Yue, Kai Wang^*, Kai Cheng, Jun Chen^*, Xiaogang Luo, Tao Zhang. Small-molecule porphyrin-based organic nanoparticles with remarkable photothermal conversion efficiency for in vivo photoacoustic imaging and photothermal therapy. ACS Applied materials & Interfaces, 2019, 11, 2408-21416.

2.      Yi-Mei Zhao, Qian-Qian Lu, Si Yao, Hui-Fang Su, Hong-Jian Liu, Ze-Jiang Wang, Feng-Shou Wu, Kai Wang^*. N-Methylpyridylporphyrin tailed with folate conjugate as a potential lysosomal-targeted photosensitizer: synthesis, DNA interaction, singlet oxygen and subcellular localization. Journal of Porphyrins and Phthalocyanines, 2019, 23 (6), 679-684.

3.      Jun Jiang^†, Dan Liu^†, Yimei Zhao, Fengshou Wu*, Ke Yang, Kai Wang*. Synthesis, DNA binding mode, singlet oxygen photogeneration and DNA photocleavage activity of ruthenium compounds with porphyrin–imidazo[4,5‐f] phenanthroline conjugated ligand. Applied Organometallic Chemistry, 2018, 32 (9), e4468.

4.      Ji Zhou,Kai Wang*, Xiulan Zhang, Cunwen Wang*. The comparison between series and parallel: Integrated experimental teaching model for pharmaceutical engineering students based on criteria for accrediting engineering programs in China. Journal of Cleaner Production, 2018, 172, 4421-4434.

5.      Sizhe Zhu, Si Yao, Fengshou Wu*, Lijun Jiang, Ka-Leung Wong*, Ji Zhou, Kai Wang*. Platinated Porphyrin as a New Organelle and Nucleus Dual-targeted Photosensitizer for Photodynamic Therapy. Organic & Biomolecular Chemistry. 2017, 15 (27), 5764-5771.

6.      孙新宇, 周霁, 吴风收, 王凯^*. 奥拉西坦的合成. 中国医药工业杂志, 2017, 48 (4), 503-505.

7.      Sizhe Zhu, Fengshou Wu, Kai Wang*, Yunman Zheng, Zaoying Li*, Xiulan Zhang, Wai-Kwok Wong*. Photocytotoxicity, cellular uptake and subcellular localization of amidinophenylporphyrins as potential photodynamic therapeutic agents: an in vitro cell study. Bioorganic & Medicinal Chemistry Letters,2015, 25 (20), 4513-4517.

8.      王凯、徐洪斌、喻发全等. 6-甲氧基哒嗪-3-羧酸的合成工艺（2015F-042-3-020-004-R01），获得湖北省科学技术奖发明奖三等奖，2015年。

9.      王凯, 宋率华, 喻发全, 张珩, 张秀兰, 刘子维. 地尔硫卓中间体副产物L-cis-内酰胺的回收工艺. ZL201410037598.1, 2016-02-24授权.

10.   Kai Wang, Chun-Ting Poon, Wai-Kwok Wong, Wai-Yeung Wong, Daniel W. J. Kwong, Heng Zhang, Zao-Ying Li. Synthesis, Characterization, Singlet Oxygen Photogeneration, DNA Photocleavage and Two-Photon Absorption Properties of Some (4-Cyanophenyl) porphyrins. European Journal of Inorganic Chemistry, 2009, 7, 922-928.